منابع مشابه
An overview of chemotherapeutic targets for antimalarial drug discovery.
The need for new antimalarials comes from the widespread resistance to those in current use. New antimalarial targets are required to allow the discovery of chemically diverse, effective drugs. The search for such new targets and new drug chemotypes will likely be helped by the advent of functional genomics and structure-based drug design. After validation of the putative targets as those capab...
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Parasitic infections due to the protozoa Plasmodium are responsible for malaria, a severe disease that still caused about 225 million cases and 781,000 human deaths in 2009, despite the efforts developed during the last decade to fight this disease (Alonso et al., 2011). The international funding allocated to antimalarial strategies has increased regularly since 2003 from about 0.3 billions to ...
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As pathogens evolve effective schemes to overcome the effect of antibiotics, the prevalent "one drug and one drug target" approach is falling behind. We propose novel strategies for identifying potential multiple-drug targets in pathogenic protein-protein interaction (PPI) networks with the goal of disrupting known pathways/complexes. Given a set S of pathogenic pathways/complexes, we first con...
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Uncovering driver genes is crucial for understanding heterogeneity in cancer. L1-type regularization approaches have been widely used for uncovering cancer driver genes based on genome-scale data. Although the existing methods have been widely applied in the field of bioinformatics, they possess several drawbacks: subset size limitations, erroneous estimation results, multicollinearity, and hea...
متن کاملUse of Gene Networks for Identifying and Validating Drug Targets
We propose a new method for identifying and validating drug targets by using gene networks, which are estimated from cDNA microarray gene expression profile data. We created novel gene disruption and drug response microarray gene expression profile data libraries for the purpose of drug target elucidation. We use two types of microarray gene expression profile data for estimating gene networks ...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2019
ISSN: 1474-1776,1474-1784
DOI: 10.1038/d41573-019-00009-8